Understanding how changes in DNA affect evolution
Structural variants and the locus of evolution
This project aims to understand how large changes in our genetic code, called structural variants, arise and influence the evolution of life.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Florida International University NIH-funded |
| Lab location | 1 site (Miami, United States) |
| Project ID | NIH-11113794 on NIH RePORTER |
What this research studies
Our genetic material, DNA, can change in many ways, from small single-letter changes to large sections being duplicated, deleted, or rearranged; these larger changes are called structural variants. While small changes have been well-studied, we are just beginning to understand the importance of these larger structural variants in how species evolve. This research will explore how these structural variants are passed down through generations and how they contribute to differences in genome size and content. By understanding these fundamental processes, we can gain insights into the building blocks of genetic diversity.
Who could benefit from this research
Good fit: This basic science project does not involve direct patient participation or recruitment.
Not a fit: Patients seeking immediate clinical treatments or direct health interventions would not receive direct benefit from this foundational research.
Why it matters
Potential benefit: This foundational knowledge could help us better understand the origins of genetic differences that contribute to human health and disease over long periods.
How similar studies have performed: Research on structural variants in evolution is a relatively new field, and this project aims to fill significant gaps in our current understanding.
Where this research is happening
Miami, United States
- Florida International University — Miami, United States (Active)
Researchers
- Principal investigator: Fierst, Janna Lynn — Florida International University
- Study coordinator: Fierst, Janna Lynn
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.