Understanding How Changes in Chromosome Arms Affect Our Cells
Functional Understanding of Chromosome Arm Aneuploidies
This research explores how gaining or losing parts of chromosomes, which happens in both healthy and diseased cells, affects our body.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Columbia University Health Sciences NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-11086849 on NIH RePORTER |
What this research studies
Our bodies' cells sometimes gain or lose whole chromosomes or just parts of them, a condition called aneuploidy, which is linked to cancer and certain birth conditions but also occurs in healthy tissues. This project aims to understand the specific effects these chromosome changes have on our cells. We are developing advanced computer programs to detect these changes in human cell data, even when they are rare. We also plan to build a comprehensive map of these chromosome changes across different healthy human tissues. Additionally, we use special lab techniques to create specific chromosome changes in human cells to directly observe how they impact cell behavior, such as cell growth.
Who could benefit from this research
Good fit: This foundational research does not directly involve patients, but future clinical studies stemming from this work might seek individuals with specific chromosome changes or related health conditions.
Not a fit: Patients looking for immediate new treatments or direct clinical care will not find direct benefit from this fundamental science project.
Why it matters
Potential benefit: This work could help us better understand and potentially develop new ways to identify or treat diseases like cancer and certain birth conditions linked to chromosome changes.
How similar studies have performed: While the presence of aneuploidy in diseases is known, this project uses new computational and lab techniques to understand the specific effects of these chromosome changes.
Where this research is happening
New York, United States
- Columbia University Health Sciences — New York, United States (Active)
Researchers
- Principal investigator: Taylor, Alison M. — Columbia University Health Sciences
- Study coordinator: Taylor, Alison M.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.