Understanding how changes in cell structure can lead to cancer progression
Official title: Phase Transitions in Chromatin Organization that cause Cancer Progression
Funded at Princeton University · NIH-10786047 · Data updated 2026-11-12
This study is looking at how changes in a protein called ARID1A can affect the structure of the cell's nucleus and contribute to cancer, using special tools to see how these changes happen in real-time in living cells.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Princeton University NIH-funded |
| Lab location | 1 site (Princeton, UNITED STATES) |
| Project start | March 1, 2023 |
| Project end | July 31, 2025 |
| Funding year | 2024 |
| Award (this year) | $120,534 |
| NIH project number | 5K99CA276887-02 |
| Project ID | NIH-10786047 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with cancers associated with mutations in the ARID1A protein.
✕Less likely to help
Patients with cancers not linked to chromatin organization or ARID1A mutations may not benefit from this research.
What this research studies
This research investigates the relationship between nuclear structure and cancer progression, focusing on how mutations in a protein called ARID1A affect chromatin organization. By examining the differences in nuclear shape and chromatin distribution between healthy and cancerous cells, the study aims to uncover the molecular mechanisms behind these changes. The researchers utilize advanced optogenetic tools to manipulate and observe the biophysical behavior of chromatin in living cells, providing insights into how these alterations contribute to cancer development.
Why it matters
Potential benefit: If successful, this research could lead to improved diagnostic methods and targeted therapies for cancer based on the understanding of chromatin organization.
How similar studies have gone: Other research has shown promising results in understanding chromatin dynamics and its implications in cancer, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Princeton University
Princeton, United States Active
Researchers
- Principal investigator: Strom, Amy — Princeton University
- Study coordinator: Strom, Amy
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.