Understanding how changes in cell regulation lead to blood cancers like leukemia
Integrated analyses of the epigenome to understand the molecular basis of hematopoietic malignancies
This study is looking at how blood cancers like leukemia develop by exploring the tiny changes in blood cells that can lead to these diseases, using a special technique to see what’s happening in individual cells.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Wistar Institute NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project ID | NIH-10918306 on NIH RePORTER |
What this research studies
This research investigates the molecular mechanisms behind blood cancers, particularly leukemia, by examining how the regulation of blood cell development goes awry. It utilizes advanced techniques to analyze changes in the epigenome, which is the chemical modifications that affect gene expression without altering the DNA sequence. By employing a novel method called scCUT&Tag, the study aims to map the activity of regulatory elements in blood cells at a single-cell level, providing insights into how these changes contribute to cancer development.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with hematopoietic malignancies, such as leukemia, or those at high risk for developing these conditions.
Not a fit: Patients with solid tumors or non-hematological cancers may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to a better understanding of leukemia, potentially paving the way for new treatments or prevention strategies.
How similar studies have performed: Previous research has shown promise in using epigenomic approaches to understand cancer biology, indicating that this methodology could yield valuable insights.
Where this research is happening
Philadelphia, United States
- Wistar Institute — Philadelphia, United States (Active)
Researchers
- Principal investigator: Srivastava, Avi — Wistar Institute
- Study coordinator: Srivastava, Avi
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.