Understanding how changes in brain cells affect white matter disease and cognitive decline.
Altered microglia states and microglia-endothelial cell axis in relation to white matter disease progression in VCID
This study is looking at how changes in brain immune cells might affect blood vessel health and contribute to problems with thinking and memory, especially in people with white matter disease and vascular cognitive impairment, to help us understand how to keep the brain healthy as we age.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Edinburgh NIH-funded |
| Lab location | 1 site (Edinburgh, United Kingdom) |
| Project ID | NIH-10930972 on NIH RePORTER |
What this research studies
This research investigates the relationship between altered states of brain immune cells (microglia) and the health of blood vessels in the brain, particularly in relation to white matter disease and vascular cognitive impairment and dementia (VCID). By examining human brain tissues and conducting studies in animal models, the research aims to uncover how these cellular interactions contribute to cognitive decline. The team will explore how microglia respond to changes in blood flow and how these responses may influence brain health and function over time.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals at risk for or experiencing vascular cognitive impairment and dementia, particularly those with white matter abnormalities.
Not a fit: Patients with cognitive impairments not related to vascular issues or those with other forms of dementia may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that improve cognitive function and slow the progression of dementia in patients.
How similar studies have performed: Previous research has shown promising results in understanding the role of microglia in brain health, suggesting that this approach could yield valuable insights.
Where this research is happening
Edinburgh, United Kingdom
- University of Edinburgh — Edinburgh, United Kingdom (Active)
Researchers
- Principal investigator: Horsburgh, Karen — University of Edinburgh
- Study coordinator: Horsburgh, Karen
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.