Understanding how changes in a specific gene affect blood vessel diseases
PTEN promoter hypermethylation underlies vascular disease progression
This study is looking at how a gene called PTEN affects blood vessel diseases like atherosclerosis and restenosis, with the hope of finding new ways to help patients by understanding how changes in this gene can harm the cells that keep our blood vessels healthy.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Colorado Denver NIH-funded |
| Lab location | 1 site (Aurora, UNITED STATES) |
| Project ID | NIH-10762945 on NIH RePORTER |
What this research studies
This research investigates the role of a gene called PTEN in the progression of vascular diseases like atherosclerosis and restenosis. It focuses on how changes in PTEN can lead to harmful transformations in vascular smooth muscle cells, which are crucial for maintaining healthy blood vessels. By examining these cellular changes, the research aims to uncover new therapeutic targets that could prevent disease progression. Patients may benefit from insights that could lead to innovative treatments for vascular disorders.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals suffering from vascular diseases, particularly those with atherosclerosis or restenosis.
Not a fit: Patients with non-vascular related conditions or those without significant vascular disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that prevent the progression of vascular diseases and improve patient outcomes.
How similar studies have performed: Previous research has shown promising results in understanding the role of PTEN in vascular diseases, indicating that this approach has potential for significant breakthroughs.
Where this research is happening
Aurora, UNITED STATES
- University of Colorado Denver — Aurora, United States (Active)
Researchers
- Principal investigator: Weiser-Evans, Mary Cm. — University of Colorado Denver
- Study coordinator: Weiser-Evans, Mary Cm.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.