Understanding how certain viruses use host cell mechanisms to replicate
Host factor contribution to positive-strand RNA virus induced membrane reorganization
['FUNDING_R01'] · EMORY UNIVERSITY · NIH-11112527
This study is looking at how viruses like dengue and Zika use our body's cells to make more copies of themselves, and it hopes to find new ways to stop these viruses from spreading, which is especially important as these infections are becoming more common.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | EMORY UNIVERSITY (nih funded) |
| Locations | 1 site (ATLANTA, UNITED STATES) |
| Trial ID | NIH-11112527 on ClinicalTrials.gov |
What this research studies
This research investigates how positive-sense single-strand RNA viruses, such as dengue and Zika viruses, interact with host cells to facilitate their replication. By examining the role of specific host proteins in the viral replication process, the study aims to uncover potential targets for antiviral therapies. The research employs advanced cellular biology techniques to analyze the mechanisms of virus-host interactions and seeks to identify ways to disrupt these processes to prevent viral infections. This work is particularly relevant given the increasing incidence of these viruses due to climate change and population movement.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research include individuals at risk for infections from flaviviruses, such as those living in or traveling to endemic areas.
Not a fit: Patients who are not at risk for flavivirus infections or those with existing effective treatments may not receive benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to the development of new antiviral treatments that effectively combat infections caused by these viruses.
How similar studies have performed: Previous research has shown promise in understanding virus-host interactions, indicating that this approach could yield valuable insights and potential breakthroughs.
Where this research is happening
ATLANTA, UNITED STATES
- EMORY UNIVERSITY — ATLANTA, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: NEUFELDT, CHRISTOPHER — EMORY UNIVERSITY
- Study coordinator: NEUFELDT, CHRISTOPHER
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.