Understanding how certain viruses use host cell mechanisms to replicate
Official title: Host factor contribution to positive-strand RNA virus induced membrane reorganization
Funded at Emory University · NIH-11112527 · Data updated 2026-11-12
This study is looking at how viruses like dengue and Zika use our body's cells to make more copies of themselves, and it hopes to find new ways to stop these viruses from spreading, which is especially important as these infections are becoming more common.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Emory University NIH-funded |
| Lab location | 1 site (Atlanta, United States) |
| Project start | June 11, 2024 |
| Project end | April 30, 2029 |
| Funding year | 2025 |
| Award (this year) | $487,184 |
| NIH project number | 5R01AI185849-02 |
| Project ID | NIH-11112527 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation or benefit from this research include individuals at risk for infections from flaviviruses, such as those living in or traveling to endemic areas.
✕Less likely to help
Patients who are not at risk for flavivirus infections or those with existing effective treatments may not receive benefit from this research.
What this research studies
This research investigates how positive-sense single-strand RNA viruses, such as dengue and Zika viruses, interact with host cells to facilitate their replication. By examining the role of specific host proteins in the viral replication process, the study aims to uncover potential targets for antiviral therapies. The research employs advanced cellular biology techniques to analyze the mechanisms of virus-host interactions and seeks to identify ways to disrupt these processes to prevent viral infections. This work is particularly relevant given the increasing incidence of these viruses due to climate change and population movement.
Why it matters
Potential benefit: If successful, this research could lead to the development of new antiviral treatments that effectively combat infections caused by these viruses.
How similar studies have gone: Previous research has shown promise in understanding virus-host interactions, indicating that this approach could yield valuable insights and potential breakthroughs.
Where this research is happening
-
Emory University
Atlanta, United States Active
Researchers
- Principal investigator: Neufeldt, Christopher — Emory University
- Study coordinator: Neufeldt, Christopher
Related research
Other NIH-funded projects on the same topics.
-
Administrative and Engagement Core for Breast Cancer Breakthrough in Kenya
A national effort in Kenya to speed up how we screen for breast cancer and connect women to treatment, using teamwork across institutions.
-
Collaborative research program to advance patient care
A multi-project research effort at Emory University aims to push forward medical knowledge that could help people with illnesses in the future.
-
Project-003: A multi-partner research program at Emory University
A multi-faceted NIH grant at Emory University aims to advance understanding in a focused area over several years to benefit patients with diseases or conditions connected to the research.
-
Project-002: advancing patient care through coordinated research at Emory
A multi-project NIH grant at Emory aims to translate findings into better care for people with a health condition by coordinating research efforts across teams.
-
Project-006: A Multidisciplinary Emory Initiative to Advance Medical Understanding
A multi-project NIH grant at Emory University aims to push forward medical knowledge in areas that could eventually help patients.
-
Project-005: A multi-component research effort at Emory University
A multi-part NIH grant from Emory University aims to advance understanding in a specific health area over several years with potential patient benefits in the future.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.