Understanding how certain viruses translate their genomes without a cap structure
Structural and mechanistic studies of cap-independent genome translation in (+)-strand RNA viruses
['FUNDING_OTHER'] · UNIVERSITY OF MARYLAND BALTIMORE COUNTY · NIH-10901883
This study is looking at how certain RNA viruses start making their proteins without using the usual methods, focusing on special parts of their genetic material that help them hijack the cell's machinery, and the findings could help us understand these viruses better and find new ways to treat infections.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF MARYLAND BALTIMORE COUNTY (nih funded) |
| Locations | 1 site (BALTIMORE, UNITED STATES) |
| Trial ID | NIH-10901883 on ClinicalTrials.gov |
What this research studies
This research investigates the mechanisms by which certain RNA viruses initiate the translation of their genomes without relying on the traditional cap structure. It focuses on internal ribosome entry sites (IRESs) and 3' cap-independent translation enhancers (3'CITEs) that allow these viruses to effectively recruit the necessary components from the host cell. Using advanced techniques like X-ray crystallography, the researchers aim to uncover the three-dimensional structures of these viral elements, which could reveal how they interact with ribosomes and other cellular factors. This knowledge may lead to new insights into viral behavior and potential therapeutic targets.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals affected by diseases caused by (+)-strand RNA viruses, such as those caused by coxsackievirus or hepatitis A virus.
Not a fit: Patients with conditions unrelated to (+)-strand RNA viruses may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to the development of novel antiviral therapies targeting the translation mechanisms of RNA viruses.
How similar studies have performed: While the specific approach of studying IRESs and 3'CITEs in this context is relatively novel, similar structural studies have previously shown promise in understanding viral mechanisms.
Where this research is happening
BALTIMORE, UNITED STATES
- UNIVERSITY OF MARYLAND BALTIMORE COUNTY — BALTIMORE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: KOIRALA, DEEPAK — UNIVERSITY OF MARYLAND BALTIMORE COUNTY
- Study coordinator: KOIRALA, DEEPAK
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Animal Diseases