Understanding how certain viruses remain stable in extreme conditions
Official title: Determining the molecular basis for extreme virus stability, a structure-guided approach
Funded at Portland State University · NIH-11116890 · Data updated 2026-11-12
This study is looking at a special virus that can survive really hot and acidic conditions to help scientists understand how it stays strong, which could eventually lead to better treatments for viral infections.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Portland State University NIH-funded |
| Lab location | 1 site (Portland, United States) |
| Project start | July 1, 2024 |
| Project end | April 30, 2028 |
| Funding year | 2025 |
| Award (this year) | $149,417 |
| NIH project number | 5R16GM154184-02 |
| Project ID | NIH-11116890 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation or benefit from this research would include individuals with a keen interest in viral infections or those affected by viral diseases.
✕Less likely to help
Patients with non-viral related health issues may not receive any direct benefit from this research.
What this research studies
This research investigates the unique stability of the Sulfolobus Spindle-shaped Virus 1 (SSV1), which can withstand high temperatures and low pH levels. By using advanced techniques like site-directed mutagenesis and cryo-electron microscopy, researchers aim to identify the specific amino acids in the virus's capsid protein that contribute to its resilience. This study not only explores the genetic and biochemical factors behind this stability but also develops tools for further research and education in the field. Patients may benefit indirectly through advancements in viral research that could lead to improved treatments for viral infections.
Why it matters
Potential benefit: If successful, this research could lead to breakthroughs in understanding viral stability, potentially informing new therapeutic strategies against viral diseases.
How similar studies have gone: While the specific approach of studying extreme virus stability is relatively novel, similar research has shown promise in understanding viral mechanisms and developing treatments.
Where this research is happening
-
Portland State University
Portland, United States Active
Researchers
- Principal investigator: Stedman, Kenneth Mark — Portland State University
- Study coordinator: Stedman, Kenneth Mark
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.