Understanding how certain viruses produce their genetic material and evolve
Constructing the nest - understanding the mechanisms of nidoviridae RNA genomes transcription and recombination
This study is looking at how certain viruses, like coronaviruses, make copies of their genetic material and change over time, which could help us find new ways to treat viral infections that affect people.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Harvard Medical School NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-10472116 on NIH RePORTER |
What this research studies
This research investigates the mechanisms by which Nidoviridae viruses, including coronaviruses, transcribe their RNA genomes and undergo genetic recombination. By examining the processes of discontinuous transcription and the role of host proteins, the study aims to uncover how these viruses adapt and evolve. The research employs high-throughput techniques to analyze viral RNA production and its implications for viral evolution. Patients may benefit from insights gained that could lead to new therapeutic strategies against viral infections.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research include individuals affected by viral infections, particularly those caused by coronaviruses.
Not a fit: Patients with non-viral infections or those not affected by coronaviruses may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to the development of new treatments for viral infections, improving patient outcomes.
How similar studies have performed: Previous research has shown success in understanding viral mechanisms, but this specific approach to studying Nidoviridae is relatively novel.
Where this research is happening
Boston, United States
- Harvard Medical School — Boston, United States (Active)
Researchers
- Principal investigator: Rouskin, Silvia — Harvard Medical School
- Study coordinator: Rouskin, Silvia
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.