Understanding how certain viruses organize their genetic material
Molecular and cellular biology of the phage nucleus and spindle
This study is looking at how certain large viruses, called jumbo phages, organize their genetic material inside a host cell, which could help us understand how they work and lead to better treatments for viral infections.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Diego NIH-funded |
| Lab location | 1 site (La Jolla, United States) |
| Project ID | NIH-10915435 on NIH RePORTER |
What this research studies
This research investigates the complex organization of a unique structure called the 'phage nucleus' found in certain viruses known as jumbo phages. By examining how these phages replicate and manage their genetic material within a host cell, the study aims to identify the proteins involved in forming this nucleus-like structure. The approach combines genetic techniques and advanced imaging methods to uncover the roles of these proteins in viral biology. Patients may benefit from insights gained into viral behavior, which could inform future treatments for viral infections.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research would include individuals with viral infections or those interested in the mechanisms of viral diseases.
Not a fit: Patients with non-viral related conditions or those not affected by viral infections may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for combating viral infections by enhancing our understanding of viral replication and organization.
How similar studies have performed: Other research has shown success in understanding viral structures and their functions, but this specific investigation into the phage nucleus is relatively novel.
Where this research is happening
La Jolla, United States
- University of California, San Diego — La Jolla, United States (Active)
Researchers
- Principal investigator: Pogliano, Joseph a — University of California, San Diego
- Study coordinator: Pogliano, Joseph a
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.