Understanding how certain T cells contribute to malaria disease
Pathogenic low affinity CD8 T cells in malaria
This study is looking at how certain immune cells called CD8 T cells respond to malaria, trying to figure out which features help them fight the infection effectively and which might make things worse, with the goal of improving treatments and vaccines for malaria.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Utah NIH-funded |
| Lab location | 1 site (Salt Lake City, United States) |
| Project ID | NIH-10906883 on NIH RePORTER |
What this research studies
This research investigates the role of CD8 T cells in malaria infections, focusing on how their affinity for specific antigens influences their function and the overall immune response. By analyzing T cell populations, the researchers aim to identify which characteristics lead to beneficial immune responses versus those that contribute to disease pathology. The study combines advanced techniques in T cell biology to measure the affinity profiles of these cells, providing insights into the mechanisms that drive malaria-related complications. This work is crucial for developing better treatments and vaccines against malaria.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who have been diagnosed with malaria or are at high risk of malaria infection.
Not a fit: Patients who do not have malaria or are not at risk for malaria will likely not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for treating and preventing malaria by enhancing the immune response.
How similar studies have performed: Previous research has shown promising results in understanding T cell responses in other infectious diseases, suggesting that this approach could yield valuable insights for malaria as well.
Where this research is happening
Salt Lake City, United States
- University of Utah — Salt Lake City, United States (Active)
Researchers
- Principal investigator: Lamb, Tracey Jane — University of Utah
- Study coordinator: Lamb, Tracey Jane
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.