Understanding how certain stomach cells can lead to gastric cancer
Cell plasticity in the origin of gastric carcinogenesis
This study is looking at special stomach cells that might help us understand how some stomach issues can turn into cancer, with the hope that what we learn could lead to better ways to prevent or treat gastric cancer for patients like you.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Vanderbilt University Medical Center NIH-funded |
| Lab location | 1 site (Nashville, United States) |
| Project ID | NIH-10912694 on NIH RePORTER |
What this research studies
This research investigates the role of specific stomach cells, known as spasmolytic polypeptide-expressing metaplasia (SPEM) cells, in the development of gastric cancer. It aims to understand how these cells can change and contribute to the progression from pre-cancerous conditions to cancerous states. By using advanced techniques like ATAC sequencing and CRISPR, the study will explore the genetic and epigenetic changes that occur during this process. Patients may benefit from insights that could lead to new prevention or treatment strategies for gastric cancer.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with pre-cancerous gastric conditions or those at high risk for gastric cancer.
Not a fit: Patients with established gastric cancer or those without any gastric conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for preventing or treating gastric cancer.
How similar studies have performed: Other research has shown promising results in understanding cancer progression through similar cellular and genetic approaches.
Where this research is happening
Nashville, United States
- Vanderbilt University Medical Center — Nashville, United States (Active)
Researchers
- Principal investigator: Choi, Eunyoung — Vanderbilt University Medical Center
- Study coordinator: Choi, Eunyoung
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.