Understanding how certain signals cause nerve cell death
Mechanisms of renin-angiotensin signaling in programmed and insult-induced neuronal death
['FUNDING_R01'] · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · NIH-10906184
This study is looking at how certain signals in the brain can cause nerve cells to die and how a special treatment might help protect these cells, using zebrafish to learn more about conditions like Gaucher disease and Parkinson's disease.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF CALIFORNIA, SAN FRANCISCO (nih funded) |
| Locations | 1 site (SAN FRANCISCO, UNITED STATES) |
| Trial ID | NIH-10906184 on ClinicalTrials.gov |
What this research studies
This research investigates the mechanisms behind programmed and injury-induced death of nerve cells, focusing on a specific signaling pathway in the brain. Using zebrafish as a model, the study explores how inhibitors of the renin-angiotensin system can protect neurons from dying in both normal development and disease conditions. By examining the interactions between neurons and supporting cells, the research aims to uncover new insights into neurodegeneration, particularly in conditions like Gaucher disease and Parkinson's disease.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals affected by neurodegenerative diseases, particularly those with Gaucher disease or Parkinson's disease.
Not a fit: Patients with neurodegenerative conditions not related to the renin-angiotensin system may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that protect nerve cells from degeneration, improving outcomes for patients with neurodegenerative diseases.
How similar studies have performed: Previous research has shown promise in using similar signaling pathway approaches to protect neurons, indicating potential for success in this area.
Where this research is happening
SAN FRANCISCO, UNITED STATES
- UNIVERSITY OF CALIFORNIA, SAN FRANCISCO — SAN FRANCISCO, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: GUO, SU — UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
- Study coordinator: GUO, SU
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.