Understanding how certain signals affect the development of left-right body asymmetry
Linking Hedgehog and Nodal/TGF-beta signaling in the establishment of left-right asymmetry
This study is looking at how tiny signals in developing embryos help decide which side is left and which side is right, which is really important for making sure organs like the heart and lungs are in the right place, and it could help us understand why some babies are born with heart or lung problems.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | George Washington University NIH-funded |
| Lab location | 1 site (Washington, United States) |
| Project ID | NIH-11136207 on NIH RePORTER |
What this research studies
This research investigates the biological processes that establish left-right asymmetry in developing embryos, which is crucial for the proper positioning of internal organs. It focuses on the interaction between Hedgehog and Nodal/TGF-beta signaling pathways, which are essential for organ development. By studying these pathways in model organisms, the research aims to uncover how disruptions in these signals can lead to congenital defects. The findings could provide insights into the mechanisms behind various birth defects affecting the heart, lungs, and other organs.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research include individuals with congenital abnormalities affecting organ placement or function.
Not a fit: Patients with congenital defects unrelated to left-right asymmetry may not receive benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and potential prevention of congenital defects related to left-right asymmetry.
How similar studies have performed: Previous research has shown success in understanding signaling pathways related to congenital defects, indicating that this approach has potential for meaningful discoveries.
Where this research is happening
Washington, United States
- George Washington University — Washington, United States (Active)
Researchers
- Principal investigator: Zheng, Xiaoyan — George Washington University
- Study coordinator: Zheng, Xiaoyan
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.