Understanding how certain signals affect the development of left-right body asymmetry
Linking Hedgehog and Nodal/TGF-beta signaling in the establishment of left-right asymmetry
['FUNDING_R01'] · GEORGE WASHINGTON UNIVERSITY · NIH-10895457
This study is looking at how certain signals in developing embryos help determine the left and right sides of the body, which is important for making sure organs like the heart and lungs are in the right place, and it uses mice to learn more about what can go wrong when these signals don't work properly.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | GEORGE WASHINGTON UNIVERSITY (nih funded) |
| Locations | 1 site (WASHINGTON, UNITED STATES) |
| Trial ID | NIH-10895457 on ClinicalTrials.gov |
What this research studies
This research investigates the biological mechanisms that establish left-right asymmetry in developing embryos, which is crucial for the proper positioning of internal organs. It focuses on the roles of specific signaling pathways, particularly Hedgehog and Nodal/TGF-beta, in this process. By studying these pathways, researchers aim to uncover how defects in these signals can lead to congenital abnormalities, such as heart and lung defects. The approach involves using mouse models to explore the interactions between these signaling pathways and their effects on organ development.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with a family history of congenital abnormalities or those diagnosed with related birth defects.
Not a fit: Patients with congenital defects unrelated to left-right asymmetry may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and potential prevention of congenital defects related to organ positioning.
How similar studies have performed: Previous research has shown success in understanding signaling pathways related to congenital defects, indicating that this approach has potential for meaningful insights.
Where this research is happening
WASHINGTON, UNITED STATES
- GEORGE WASHINGTON UNIVERSITY — WASHINGTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: ZHENG, XIAOYAN — GEORGE WASHINGTON UNIVERSITY
- Study coordinator: ZHENG, XIAOYAN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.