Understanding how certain signaling mechanisms contribute to advanced prostate cancer
Novel Mechanisms of ROS/RNS Signaling Underlying Castration-Resistant Prostate Cancer Emergence and Progression
This study is looking at how certain factors help castration-resistant prostate cancer grow and how combining standard treatments with specific FDA-approved drugs might make those treatments work better for patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Miami School of Medicine NIH-funded |
| Lab location | 1 site (Coral Gables, United States) |
| Project ID | NIH-10873107 on NIH RePORTER |
What this research studies
This research investigates the molecular factors that lead to the emergence and progression of castration-resistant prostate cancer (CRPC). By analyzing patient data and using an early CRPC model, the team aims to understand how stimulating the nitric oxide receptor complex can be beneficial when combined with standard androgen deprivation therapy. The study explores the potential of FDA-approved drugs to enhance treatment effectiveness by targeting specific signaling pathways involved in cancer growth. Patients may be involved in trials assessing the impact of these treatments on tumor growth and progression.
Who could benefit from this research
Good fit: Ideal candidates for this research are men diagnosed with castration-resistant prostate cancer who have limited treatment options.
Not a fit: Patients with early-stage prostate cancer or those not resistant to castration therapies may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatment strategies for patients with advanced prostate cancer.
How similar studies have performed: Previous research has shown promising results with similar approaches targeting nitric oxide signaling in cancer treatment.
Where this research is happening
Coral Gables, United States
- University of Miami School of Medicine — Coral Gables, United States (Active)
Researchers
- Principal investigator: Rai, Priyamvada — University of Miami School of Medicine
- Study coordinator: Rai, Priyamvada
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.