Understanding how certain RNA molecules influence behavior related to alcohol use
LNCRNA REGULATION OF GENE EXPRESSION & BEHAVIOR
This research explores how specific non-coding RNA molecules in the brain affect gene activity and behavior, especially in the context of alcohol use disorder.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pittsburgh at Pittsburgh NIH-funded |
| Lab location | 1 site (Pittsburgh, United States) |
| Project ID | NIH-11112411 on NIH RePORTER |
What this research studies
Alcohol use disorder is a significant health challenge, and we know that alcohol changes how genes work in different parts of the brain. This project focuses on long non-coding RNAs (lncRNAs), which are a type of genetic material that doesn't make proteins but plays a crucial role in controlling how other genes are expressed. We aim to discover how these lncRNAs contribute to the brain's response to alcohol and influence behaviors associated with alcohol use disorder. By understanding these fundamental processes, we hope to uncover new ways to help people affected by this condition.
Who could benefit from this research
Good fit: This foundational research is not directly recruiting patients but focuses on understanding the biological mechanisms relevant to individuals with alcohol use disorder.
Not a fit: Patients without alcohol use disorder or related neurological conditions may not directly benefit from this specific research.
Why it matters
Potential benefit: If successful, this work could identify new biological targets for developing more effective treatments for alcohol use disorder.
How similar studies have performed: Previous studies have shown that lncRNAs are critical for regulating gene expression and alternative splicing, suggesting this approach builds on established biological roles.
Where this research is happening
Pittsburgh, United States
- University of Pittsburgh at Pittsburgh — Pittsburgh, United States (Active)
Researchers
- Principal investigator: Farris, Sean P — University of Pittsburgh at Pittsburgh
- Study coordinator: Farris, Sean P
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.