Understanding how certain RNA molecules are translated and degraded in cells
Official title: Translation, targeting, and decay of yeast nonsense-containing mRNAs
Funded at Univ of Massachusetts Med Sch Worcester · NIH-10906732 · Data updated 2026-11-12
This study is looking at how certain faulty RNA molecules are handled in cells, using yeast to learn more about a process that helps get rid of these mistakes, which could help us understand genetic diseases related to similar RNA problems.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Univ of Massachusetts Med Sch Worcester NIH-funded |
| Lab location | 1 site (Worcester, United States) |
| Project start | August 15, 2023 |
| Project end | July 31, 2028 |
| Funding year | 2024 |
| Award (this year) | $577,959 |
| NIH project number | 5R35GM148277-02 |
| Project ID | NIH-10906732 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with genetic disorders caused by nonsense mutations or RNA splicing defects.
✕Less likely to help
Patients with conditions unrelated to RNA translation or degradation mechanisms may not benefit from this research.
What this research studies
This research investigates the processes by which specific RNA molecules, particularly those with premature translation termination, are translated and subsequently degraded in cells. It focuses on understanding the mechanisms of nonsense-mediated mRNA decay (NMD), which is a quality control pathway that eliminates faulty mRNAs. By studying yeast as a model organism, the research aims to uncover how proteins involved in this process recognize and respond to errors during translation. This could provide insights into genetic diseases caused by similar RNA issues.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for treating genetic diseases linked to RNA translation errors.
How similar studies have gone: Previous studies have shown promising results in understanding nonsense-mediated decay in various organisms, indicating that this approach has potential for success.
Where this research is happening
-
Univ of Massachusetts Med Sch Worcester
Worcester, United States Active
Researchers
- Principal investigator: Jacobson, Allan S — Univ of Massachusetts Med Sch Worcester
- Study coordinator: Jacobson, Allan S
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.