Understanding how certain RNA molecules are made and function in cells
Official title: Biogenesis of mRNA-derived telomerase long noncoding RNA
Funded at Arizona State University-Tempe Campus · NIH-11059908 · Data updated 2026-11-12
This study is looking at how a special type of RNA, important for keeping cells healthy and potentially helping cancer cells grow, is made in a certain fungus, and the findings could help us understand more about cancer and improve treatments for patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Arizona State University-Tempe Campus NIH-funded |
| Lab location | 1 site (Tempe, United States) |
| Project start | May 16, 2023 |
| Project end | March 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $279,137 |
| NIH project number | 5R01GM149864-03 |
| Project ID | NIH-11059908 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation or benefit from this research would include individuals with cancers that exhibit telomerase activity.
✕Less likely to help
Patients with non-cancerous conditions or those not affected by telomerase-related processes may not receive any benefit from this research.
What this research studies
This research investigates the biogenesis of telomerase long noncoding RNA, which plays a crucial role in maintaining genomic stability and cellular immortality, particularly in cancer and stem cells. By studying a specific fungus, Ustilago maydis, the project aims to uncover the mechanisms behind the production of this RNA and how it differs across various organisms. The research employs advanced molecular biology techniques to analyze RNA transcription processes and their implications for cellular function. Patients may benefit from insights gained into how these RNA molecules influence cancer cell behavior and stability.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for targeting cancer cells and improving treatments.
How similar studies have gone: Other research has shown promising results in understanding RNA biogenesis and its implications for cancer, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Arizona State University-Tempe Campus
Tempe, United States Active
Researchers
- Principal investigator: Chen, Julian J-L — Arizona State University-Tempe Campus
- Study coordinator: Chen, Julian J-L
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.