Understanding how certain RNA molecules activate the immune response against viruses
dsRNA regulation of the cytosolic innate immune system
['FUNDING_R01'] · EMORY UNIVERSITY · NIH-11076346
This study is looking at how certain RNA molecules help your body fight off viral infections, focusing on proteins that can detect viruses and kickstart your immune response, with the hope of finding new ways to boost antiviral treatments for patients like you.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | EMORY UNIVERSITY (nih funded) |
| Locations | 1 site (ATLANTA, UNITED STATES) |
| Trial ID | NIH-11076346 on ClinicalTrials.gov |
What this research studies
This research investigates the role of specific RNA molecules in activating the body's innate immune response to viral infections. It focuses on the 2’-5’-oligoadenylate synthetase (OAS) proteins, which detect double-stranded RNA from viruses and initiate a response to limit viral replication. By studying the structures and activation mechanisms of these proteins, the research aims to uncover how they can be effectively triggered to enhance antiviral responses. Patients may benefit from insights that could lead to new antiviral therapies.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with viral infections, particularly those caused by coronaviruses.
Not a fit: Patients with non-viral infections or those not affected by the immune response mechanisms being studied may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to the development of novel antiviral treatments that enhance the body's natural immune response to viral infections.
How similar studies have performed: Previous research has shown promising results in understanding the activation of immune responses by RNA molecules, suggesting that this approach has potential for success.
Where this research is happening
ATLANTA, UNITED STATES
- EMORY UNIVERSITY — ATLANTA, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: CONN, GRAEME L — EMORY UNIVERSITY
- Study coordinator: CONN, GRAEME L
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.