Understanding how certain retinal cells survive in a mouse model of Retinitis Pigmentosa
Elucidating the molecular and cellular mechanisms underlying cone survival in the peripheral retina in mouse models of Retinitis Pigmentosa
This study is looking at how certain cells in the eye can stay healthy even when other cells are damaged in people with Retinitis Pigmentosa, and it hopes to find new ways to help protect vision for those affected by this condition.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Massachusetts Eye and Ear Infirmary NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-11127422 on NIH RePORTER |
What this research studies
This research investigates the mechanisms that allow cone photoreceptors in the peripheral retina to survive in mouse models of Retinitis Pigmentosa, a condition that leads to vision loss. By using advanced techniques such as RNA sequencing and gene deletion, the researchers aim to identify factors that contribute to the survival of these cells after rod photoreceptor degeneration. The findings could pave the way for new therapies that protect vision in patients with this inherited retinal disease.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with Retinitis Pigmentosa, particularly those experiencing vision loss due to cone degeneration.
Not a fit: Patients with Retinitis Pigmentosa who have not experienced any degeneration of their cone photoreceptors may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that preserve vision in individuals affected by Retinitis Pigmentosa.
How similar studies have performed: Previous research has shown promising results in understanding retinal cell survival mechanisms, but this specific approach focusing on peripheral cone survival is relatively novel.
Where this research is happening
Boston, United States
- Massachusetts Eye and Ear Infirmary — Boston, United States (Active)
Researchers
- Principal investigator: Amamoto, Ryoji — Massachusetts Eye and Ear Infirmary
- Study coordinator: Amamoto, Ryoji
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.