Understanding how certain receptors work inside cells to improve drug responses
Endosomes as a multifunctional hub to control GPCR function
['FUNDING_OTHER'] · OREGON HEALTH & SCIENCE UNIVERSITY · NIH-10831040
This study is looking at how certain important receptors in our cells, which help many medications work, behave when they’re inside the cell instead of on the surface, to better understand how this affects how well drugs work and their safety.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | OREGON HEALTH & SCIENCE UNIVERSITY (nih funded) |
| Locations | 1 site (PORTLAND, UNITED STATES) |
| Trial ID | NIH-10831040 on ClinicalTrials.gov |
What this research studies
This research investigates the behavior of G protein-coupled receptors (GPCRs), which are crucial for many medications, inside cells. Traditionally, these receptors were thought to be inactive when not on the cell surface, but recent findings show they can still signal from within endosomes. The study aims to uncover how the sorting of these receptors at endosomes affects their signaling and drug response, using advanced techniques like genetic engineering and proteomics. By focusing on specific receptors, the research seeks to enhance our understanding of their roles in drug efficacy and safety.
Who could benefit from this research
Good fit: Patients who are currently using medications that target GPCRs, particularly those related to the beta-2 adrenergic receptor, may benefit from this research.
Not a fit: Patients who do not use GPCR-targeting medications or have conditions unrelated to GPCR signaling may not receive benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved drug therapies by optimizing how medications interact with GPCRs inside cells.
How similar studies have performed: While the exploration of GPCR signaling has been studied, the specific focus on endosomal sorting and its implications for drug response is a relatively novel approach.
Where this research is happening
PORTLAND, UNITED STATES
- OREGON HEALTH & SCIENCE UNIVERSITY — PORTLAND, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: LOBINGIER, BRADEN — OREGON HEALTH & SCIENCE UNIVERSITY
- Study coordinator: LOBINGIER, BRADEN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.