Understanding how certain receptors in the kidneys affect blood pressure regulation
N-methyl-D-aspartate receptors (NMDAr) participates in renal hemodynamic regulation and blood pressure homeostasis
This study is looking at how certain receptors in the kidneys help control blood flow and salt balance, which are important for keeping blood pressure healthy, especially in people with high blood pressure that doesn't have a clear cause.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Emory University NIH-funded |
| Lab location | 1 site (Atlanta, United States) |
| Project ID | NIH-11013827 on NIH RePORTER |
What this research studies
This research investigates the role of N-methyl-D-aspartate receptors (NMDAr) in regulating blood flow and sodium excretion in the kidneys, which are crucial for maintaining healthy blood pressure. By studying how these receptors interact with kidney mechanisms, the research aims to uncover the underlying causes of hypertension, particularly in cases where the cause is unknown. The approach includes both laboratory experiments and studies in specially bred mice to observe the effects of NMDAr on kidney function. The ultimate goal is to identify new therapeutic targets for treating hypertension.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals suffering from hypertension, especially those with unknown causes of their condition.
Not a fit: Patients with hypertension that is clearly linked to identifiable causes, such as kidney disease or hormonal disorders, may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for hypertension, potentially improving the health and quality of life for millions of patients.
How similar studies have performed: Previous research has shown that understanding receptor mechanisms in the kidneys can lead to significant advancements in hypertension treatment, indicating a promising avenue for this investigation.
Where this research is happening
Atlanta, United States
- Emory University — Atlanta, United States (Active)
Researchers
- Principal investigator: Romero, Cesar Andres — Emory University
- Study coordinator: Romero, Cesar Andres
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.