Understanding how certain receptors in the brain are regulated
Official title: Mechanisms of Regulation of Metabotropic Glutamate Receptors
Funded at Weill Medical Coll of Cornell Univ · NIH-11080241 · Data updated 2026-11-12
This study is looking at how certain brain proteins help control the activity of receptors that are important for mood and mental health, with the goal of finding new ways to treat conditions like depression and anxiety.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Weill Medical Coll of Cornell Univ NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | May 1, 2023 |
| Project end | April 30, 2028 |
| Funding year | 2025 |
| Award (this year) | $647,860 |
| NIH project number | 5R01NS129904-03 |
| Project ID | NIH-11080241 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals suffering from neurological or psychiatric disorders, as well as certain types of cancer.
✕Less likely to help
Patients with conditions unrelated to the functioning of metabotropic glutamate receptors may not benefit from this research.
What this research studies
This research investigates the mechanisms by which metabotropic glutamate receptors (mGluRs) are regulated in the brain. It focuses on the role of β-arrestins, which are proteins that help control the activity and signaling of these receptors. By using advanced biophysical techniques, the research aims to uncover how different types of mGluRs function and how they can be targeted for therapeutic purposes in neurological and psychiatric disorders. This could lead to better understanding and treatment options for conditions like depression, anxiety, and certain cancers.
Why it matters
Potential benefit: If successful, this research could lead to new and more effective treatments for neurological and psychiatric disorders.
How similar studies have gone: Previous research has shown promise in understanding GPCR regulation, but this specific focus on mGluRs is relatively novel.
Where this research is happening
-
Weill Medical Coll of Cornell Univ
New York, United States Active
Researchers
- Principal investigator: Levitz, Joshua — Weill Medical Coll of Cornell Univ
- Study coordinator: Levitz, Joshua
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.