Understanding how certain receptors in the body signal through different shapes.
The Role of Intermediate Conformations in G Protein-coupled Receptor Signaling
This study is looking at how a specific receptor in your body, called the adenosine A2A receptor, works when it interacts with certain medications, which could help create treatments with fewer side effects for people who need them.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of South Florida NIH-funded |
| Lab location | 1 site (Tampa, United States) |
| Project ID | NIH-11052519 on NIH RePORTER |
What this research studies
This research investigates the signaling mechanisms of G protein-coupled receptors (GPCRs), specifically focusing on the adenosine A2A receptor. By using advanced techniques like 19F nuclear magnetic resonance (NMR) spectroscopy, the study aims to identify and characterize intermediate conformational states of these receptors that are activated by partial agonists. These intermediate states may lead to reduced side effects compared to full agonists, providing insights into how these receptors communicate within cells. The research will explore the interactions of these states with G proteins to understand their signaling effects better.
Who could benefit from this research
Good fit: Ideal candidates for this research would include individuals with conditions that are treated by medications targeting adenosine A2A receptors.
Not a fit: Patients who do not have conditions related to GPCR signaling may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to the development of new medications with fewer side effects for conditions treated by targeting GPCRs.
How similar studies have performed: Previous research has shown promising results in understanding GPCR signaling, but this specific approach to studying intermediate conformational states is relatively novel.
Where this research is happening
Tampa, United States
- University of South Florida — Tampa, United States (Active)
Researchers
- Principal investigator: Ye, Libin — University of South Florida
- Study coordinator: Ye, Libin
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.