Understanding how certain receptors control cellular signaling
Official title: Novel mechanisms in the control of cAMP dynamics
Funded at University of Pittsburgh at Pittsburgh · NIH-10918288 · Data updated 2026-11-12
This study is looking at how certain receptors in our cells help control a molecule called cAMP, which is important for managing inflammation and pain, and it aims to find new ways to treat these conditions by understanding how these receptors work both on the surface and inside the cells.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pittsburgh at Pittsburgh NIH-funded |
| Lab location | 1 site (Pittsburgh, United States) |
| Project start | September 1, 2023 |
| Project end | June 30, 2027 |
| Funding year | 2024 |
| Award (this year) | $389,550 |
| NIH project number | 5R01GM148449-02 |
| Project ID | NIH-10918288 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals suffering from chronic inflammatory conditions or chronic pain.
✕Less likely to help
Patients with acute conditions or those not affected by GPCR-related signaling may not benefit from this research.
What this research studies
This research investigates the mechanisms by which G protein-coupled receptors (GPCRs) regulate the dynamics of cyclic AMP (cAMP) within cells. It explores how these receptors, traditionally thought to only function at the cell surface, can also signal from inside the cell, particularly in relation to conditions like chronic inflammation and pain. By utilizing advanced techniques such as optogenetics, the study aims to uncover new pathways and regulatory units that could lead to innovative treatments for various diseases. Patients may benefit from a deeper understanding of these signaling processes, which could inform future therapies.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for managing chronic pain and inflammation.
How similar studies have gone: Previous research has shown promising results in understanding GPCR signaling, suggesting that this approach could yield significant insights.
Where this research is happening
-
University of Pittsburgh at Pittsburgh
Pittsburgh, United States Active
Researchers
- Principal investigator: Altschuler, Daniel L — University of Pittsburgh at Pittsburgh
- Study coordinator: Altschuler, Daniel L
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.