Understanding how certain receptors affect immune responses to malaria
Official title: Role of TAM receptors in modulating humoral immunity against parasitic infections
Funded at Rosalind Franklin Univ of Medicine & Sci · NIH-10860318 · Data updated 2026-11-12
This study is looking at how certain receptors on B cells affect the immune response to malaria in people who get infected multiple times, with the hope of finding ways to help the body fight the disease better.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Rosalind Franklin Univ of Medicine & Sci NIH-funded |
| Lab location | 1 site (North Chicago, United States) |
| Project start | September 5, 2024 |
| Project end | August 31, 2029 |
| Funding year | 2024 |
| Award (this year) | $520,809 |
| NIH project number | 1R01AI182217-01 |
| Project ID | NIH-10860318 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals living in malaria-endemic regions who have experienced multiple malaria infections.
✕Less likely to help
Patients who have not been exposed to malaria or those with other unrelated health conditions may not benefit from this research.
What this research studies
This research investigates how TAM receptors on B cells influence the immune response to malaria, particularly in individuals who experience repeated infections. It aims to uncover the mechanisms behind the suboptimal immune responses that fail to provide lasting protection against the disease. By using genetic and biochemical methods, the researchers will explore how hypoxia and these receptors contribute to the accumulation of specific immune cells that may hinder effective immunity. The ultimate goal is to develop new strategies to enhance the body's ability to fight malaria.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments that enhance the immune response against malaria, potentially reducing the disease's prevalence and severity.
How similar studies have gone: Previous research has shown promise in understanding immune responses to malaria, but this specific approach focusing on TAM receptors is relatively novel.
Where this research is happening
-
Rosalind Franklin Univ of Medicine & Sci
North Chicago, United States Active
Researchers
- Principal investigator: Vijay, Rahul — Rosalind Franklin Univ of Medicine & Sci
- Study coordinator: Vijay, Rahul
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.