Understanding how certain receptors affect chronic pain and addiction.
STRUCTURE AND FUNCTION OF MRG-FAMILY RECEPTORS
This study is looking at how certain receptors in the body might help us find safer ways to relieve chronic pain without relying on opioids, especially for people with African ancestry, so that we can develop better treatments for everyone.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Univ of North Carolina Chapel Hill NIH-funded |
| Lab location | 1 site (Chapel Hill, United States) |
| Project ID | NIH-11010360 on NIH RePORTER |
What this research studies
This research investigates the role of Mas-related G protein-coupled receptors (MRGPRs) in chronic pain and addiction, focusing on how these receptors interact with opioids and other medications. By studying the mechanisms of these receptors, the research aims to identify potential non-opioid pain relief options that could reduce the risks associated with current treatments. The project will involve laboratory experiments to explore the molecular targets and their effects on pain signaling pathways, particularly in individuals with African ancestry. Patients may benefit from new therapeutic strategies that are safer and more effective for managing chronic pain.
Who could benefit from this research
Good fit: Ideal candidates for this research include adults suffering from chronic pain, particularly those who have experienced issues with opioid medications.
Not a fit: Patients who do not have chronic pain or are not affected by addiction may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to the development of safer, non-opioid medications for chronic pain management.
How similar studies have performed: Previous research has shown promise in targeting similar receptors for pain management, indicating potential for success in this approach.
Where this research is happening
Chapel Hill, United States
- Univ of North Carolina Chapel Hill — Chapel Hill, United States (Active)
Researchers
- Principal investigator: Roth, Bryan L. — Univ of North Carolina Chapel Hill
- Study coordinator: Roth, Bryan L.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.