Understanding how certain proteins work in human health and diseases like cancer
Low-complexity domain protein molecular structure, conformational dynamics, and inter-protein interactions in human health and disease
This work explores how special proteins, called low-complexity domain proteins, organize themselves in cells, which is important for understanding their role in conditions like cancer.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Connecticut Storrs NIH-funded |
| Lab location | 1 site (Storrs-Mansfield, United States) |
| Project ID | NIH-11129901 on NIH RePORTER |
What this research studies
Our bodies rely on proteins to organize themselves correctly within cells, forming structures vital for life. This project focuses on a specific type of protein, found in 30% of human proteins, that uses simple building blocks to create these important structures. When these proteins don't assemble properly, it can lead to diseases, including various cancers. We are using advanced imaging and biochemical methods to see exactly how these proteins come together and interact at a molecular level. This will help us understand the fundamental processes that go wrong in disease.
Who could benefit from this research
Good fit: This foundational research does not directly involve patient participation but aims to benefit individuals affected by diseases linked to protein assembly, such as cancers.
Not a fit: Patients seeking immediate treatment or direct clinical intervention would not receive benefit from this basic science project.
Why it matters
Potential benefit: If successful, this work could lead to a deeper understanding of how certain diseases, including cancers, develop at a basic molecular level, potentially opening doors for new treatment approaches.
How similar studies have performed: The study of low-complexity domain proteins is a relatively new and rapidly developing field, with ongoing research revealing their critical roles in various biological processes and diseases.
Where this research is happening
Storrs-Mansfield, United States
- University of Connecticut Storrs — Storrs-Mansfield, United States (Active)
Researchers
- Principal investigator: Murray, Dylan Thomas — University of Connecticut Storrs
- Study coordinator: Murray, Dylan Thomas
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.