Understanding how certain proteins regulate immune cell responses
Regulation of CD4 T cell tolerance by the NR4A family of nuclear receptors
This study is looking at how certain proteins in our immune system can help control T cells, which are important for fighting off diseases, and it aims to find new treatments that could help people with autoimmune conditions by improving how their immune system responds.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Francisco NIH-funded |
| Lab location | 1 site (San Francisco, United States) |
| Project ID | NIH-10880718 on NIH RePORTER |
What this research studies
This research investigates the role of the NR4A family of nuclear receptors in controlling T cell responses to antigens, which are substances that trigger immune reactions. By studying how these receptors function in immune-mediated diseases, the research aims to develop targeted therapies that can manipulate T cell behavior. The approach involves using small molecules to activate or inhibit these receptors, potentially leading to better management of autoimmune conditions. Patients may benefit from new treatments that improve immune tolerance and reduce harmful immune responses.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with autoimmune diseases or conditions characterized by dysregulated T cell responses.
Not a fit: Patients with non-autoimmune conditions or those not experiencing T cell-related issues may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to innovative therapies that enhance immune tolerance and treat autoimmune diseases more effectively.
How similar studies have performed: Previous research has shown promise in manipulating immune responses through similar mechanisms, indicating potential for success in this approach.
Where this research is happening
San Francisco, United States
- University of California, San Francisco — San Francisco, United States (Active)
Researchers
- Principal investigator: Zikherman, Julie — University of California, San Francisco
- Study coordinator: Zikherman, Julie
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.