Understanding how certain proteins regulate cellular functions through redox mechanisms
Official title: Mechanistic characterizations of redox regulations and functions of Arf and Rho families
Funded at University of Texas Arlington · NIH-11036628 · Data updated 2026-11-12
This study is looking at how certain proteins in our cells, called Arf and Rho, work and change when they encounter different conditions, with the hope of finding new ways to treat diseases related to these proteins.
Quick facts
| Grant type | R15 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Texas Arlington NIH-funded |
| Lab location | 1 site (Arlington, United States) |
| Project start | September 15, 2023 |
| Project end | August 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $26,084 |
| NIH project number | 3R15GM152973-01S1 |
| Project ID | NIH-11036628 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with immune system disorders or diseases related to cellular dysfunction.
✕Less likely to help
Patients with conditions unrelated to immune dysfunction or cellular processes may not benefit from this research.
What this research studies
This research investigates the roles of Arf and Rho small GTPases, which are essential for various cellular functions. The study aims to uncover how these proteins are regulated by redox-sensitive motifs, which are currently not well understood. By employing advanced techniques such as EPR and mass spectrometry, the researchers will explore the interactions and transformations of these proteins in response to redox changes. The ultimate goal is to identify new therapeutic strategies for diseases linked to these proteins by developing novel nucleotide analogs that can modulate their activity.
Why it matters
Potential benefit: If successful, this research could lead to the development of new treatments for diseases associated with immune dysfunction and other disorders linked to Arf and Rho proteins.
How similar studies have gone: While the specific approach of targeting redox-sensitive motifs in Arf and Rho proteins is novel, similar studies have shown promise in understanding protein functions and developing therapeutics.
Where this research is happening
-
University of Texas Arlington
Arlington, United States Active
Researchers
- Principal investigator: Heo, Jongyun — University of Texas Arlington
- Study coordinator: Heo, Jongyun
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.