Understanding how certain proteins regulate cellular functions and their potential therapeutic applications
Official title: Mechanistic characterizations of redox regulations and functions of Arf and Rho families
Funded at University of Texas Arlington · NIH-10796624 · Data updated 2026-11-12
This study is looking at how certain proteins in our cells work and how they are affected by changes in our body's chemistry, with the goal of finding new treatments for diseases related to these proteins that could help patients feel better.
Quick facts
| Grant type | R15 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Texas Arlington NIH-funded |
| Lab location | 1 site (Arlington, United States) |
| Project start | September 15, 2023 |
| Project end | August 31, 2026 |
| Funding year | 2023 |
| Award (this year) | $449,248 |
| NIH project number | 1R15GM152973-01 |
| Project ID | NIH-10796624 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation or benefit from this research include individuals with cardiovascular diseases or disorders linked to cellular dysfunction.
✕Less likely to help
Patients with conditions unrelated to the functions of small GTPases or those not affected by redox regulation may not receive any benefit from this research.
What this research studies
This research investigates the roles of small GTPases, specifically the Arf and Rho families of proteins, in cellular functions and how their activities are regulated by redox processes. The study aims to uncover the unknown redox regulations of these proteins, which is crucial for developing effective treatments for diseases linked to them. By employing a multidisciplinary approach that includes biochemical techniques and cell biology methods, the research seeks to identify novel therapeutic interventions targeting these proteins. Patients may benefit from new treatments developed as a result of this research.
Why it matters
Potential benefit: If successful, this research could lead to the development of new therapeutic options for diseases associated with the Arf and Rho protein families.
How similar studies have gone: While the specific focus on redox regulations of Arf and Rho proteins is novel, similar approaches in understanding protein functions have shown promise in other studies.
Where this research is happening
-
University of Texas Arlington
Arlington, United States Active
Researchers
- Principal investigator: Heo, Jongyun — University of Texas Arlington
- Study coordinator: Heo, Jongyun
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.