Understanding how certain proteins regulate cell movement and growth in cancer.
Structural and Functional Characterization of RhoGEF Regulation Using Nanodiscs to Assemble Membrane-associated Signaling Scaffolds
This study is looking at how certain proteins called RhoGEFs help control how cancer cells move and divide, which is important for understanding breast cancer and melanoma, and it hopes to find new ways to treat these types of cancer.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California at Davis NIH-funded |
| Lab location | 1 site (Davis, United States) |
| Project ID | NIH-10854895 on NIH RePORTER |
What this research studies
This research investigates the role of Rho guanine-nucleotide exchange factors (RhoGEFs) in regulating cell migration and division, which are critical processes in cancer development. By using advanced techniques like cryo-electron microscopy, the study aims to explore the complex mechanisms of these proteins at cell membranes. The goal is to uncover how RhoGEFs function as signaling scaffolds and their implications in cancer, particularly in breast cancer and melanoma. This could lead to new insights into potential therapeutic targets for cancer treatment.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with breast cancer or melanoma who may benefit from new therapeutic strategies targeting cell migration and division.
Not a fit: Patients with cancers unrelated to RhoGEF signaling or those who are not undergoing treatment for breast cancer or melanoma may not receive benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to the development of targeted therapies that inhibit RhoGEFs, potentially improving treatment outcomes for cancer patients.
How similar studies have performed: While the study of RhoGEFs is relatively novel, similar approaches targeting cell signaling pathways have shown promise in other cancer research.
Where this research is happening
Davis, United States
- University of California at Davis — Davis, United States (Active)
Researchers
- Principal investigator: Cash, Jennifer Nicole — University of California at Davis
- Study coordinator: Cash, Jennifer Nicole
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.