Understanding how certain proteins regulate cell death and inflammation in Alzheimer's disease
Inflammasome and Gasdermin Signaling Networks for Regulation of Pyroptosis and Cytokine Release
['FUNDING_P01'] · CASE WESTERN RESERVE UNIVERSITY · NIH-10861063
This study is looking at how certain proteins in our cells cause a type of cell death that leads to inflammation, which is important for understanding diseases like Alzheimer's, and it hopes to find new ways to help treat these conditions.
Quick facts
| Phase | ['FUNDING_P01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | CASE WESTERN RESERVE UNIVERSITY (nih funded) |
| Locations | 1 site (CLEVELAND, UNITED STATES) |
| Trial ID | NIH-10861063 on ClinicalTrials.gov |
What this research studies
This research investigates the complex signaling networks involved in cell death, specifically focusing on pyroptosis, a form of inflammatory cell death. By examining how proteins like Gasdermin D and caspases interact, the research aims to uncover mechanisms that lead to the release of inflammatory cytokines, which are crucial in conditions like Alzheimer's disease. The approach includes advanced molecular techniques to analyze these pathways and their implications for neurodegenerative diseases. Patients may benefit from insights that could lead to new therapeutic strategies targeting inflammation in Alzheimer's.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with Alzheimer's disease or related dementias.
Not a fit: Patients with non-neurodegenerative conditions or those without any form of dementia may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to novel treatments that reduce inflammation and improve outcomes for patients with Alzheimer's disease.
How similar studies have performed: Other research has shown promising results in targeting inflammatory pathways in neurodegenerative diseases, suggesting potential for success in this area as well.
Where this research is happening
CLEVELAND, UNITED STATES
- CASE WESTERN RESERVE UNIVERSITY — CLEVELAND, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: DUBYAK, GEORGE R — CASE WESTERN RESERVE UNIVERSITY
- Study coordinator: DUBYAK, GEORGE R
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Alzheimer disease dementia, Alzheimer syndrome, Alzheimer's Disease