Understanding how certain proteins regulate brain signaling
Official title: Mechanisms of Regulation of Neuronal GPCRs by KCTDs
Funded at Weill Medical Coll of Cornell Univ · NIH-11075332 · Data updated 2026-11-12
This study is looking at how certain proteins called KCTD help control important brain receptors that affect nerve signaling, which could lead to new insights about brain health and conditions that impact it.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Weill Medical Coll of Cornell Univ NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | May 1, 2024 |
| Project end | April 30, 2029 |
| Funding year | 2025 |
| Award (this year) | $646,104 |
| NIH project number | 5R01NS131463-02 |
| Project ID | NIH-11075332 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals with neurological conditions that may involve GABAB receptor signaling, such as epilepsy or anxiety disorders.
✕Less likely to help
Patients with conditions unrelated to GABAB receptor signaling or those not experiencing neurological issues may not benefit from this research.
What this research studies
This research investigates the role of potassium channel tetramerization domain (KCTD) proteins in regulating GABAB receptors, which are crucial for neuronal signaling. By using advanced techniques like cryo-electron microscopy and electrophysiology, the study aims to uncover the molecular mechanisms behind KCTD's influence on GABAB receptor activity. Additionally, it will explore whether KCTDs affect other neuromodulatory receptors, potentially leading to new insights into brain function and signaling pathways. The findings could enhance our understanding of how these proteins contribute to neurological health and disease.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for treating neurological disorders linked to GABAB receptor dysfunction.
How similar studies have gone: Previous research has shown promising results in understanding GPCR signaling mechanisms, indicating that this approach has potential for success.
Where this research is happening
-
Weill Medical Coll of Cornell Univ
New York, United States Active
Researchers
- Principal investigator: Levitz, Joshua — Weill Medical Coll of Cornell Univ
- Study coordinator: Levitz, Joshua
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.