Understanding how certain proteins open DNA to activate genes
Dissecting the Mechanisms of Pioneer Factor Facilitated Chromatin Opening
['FUNDING_R01'] · JOHNS HOPKINS UNIVERSITY · NIH-11036529
This study is looking at how certain proteins help turn on genes by working with the DNA in our cells, which could help us understand and find new treatments for neurological disorders and cancer.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | JOHNS HOPKINS UNIVERSITY (nih funded) |
| Locations | 1 site (BALTIMORE, UNITED STATES) |
| Trial ID | NIH-11036529 on ClinicalTrials.gov |
What this research studies
This research investigates how pioneer factors, such as Sox2 and Oct4, interact with nucleosomes to facilitate gene activation. By using advanced techniques like chemical probing assays and high-resolution nuclear magnetic resonance (NMR) spectroscopy, the study aims to uncover the molecular mechanisms behind these interactions. This could provide insights into how changes in these proteins are linked to neurological disorders and cancer. The findings may help in developing new therapeutic strategies for conditions related to gene expression.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with neurological disorders or cancers associated with mutations in pioneer factors like Sox2 and Oct4.
Not a fit: Patients with conditions unrelated to gene expression or those not affected by the mechanisms studied may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for neurological disorders and cancers by targeting the mechanisms of gene activation.
How similar studies have performed: Previous research has shown promising results in understanding gene regulation through similar molecular mechanisms, indicating potential for success in this area.
Where this research is happening
BALTIMORE, UNITED STATES
- JOHNS HOPKINS UNIVERSITY — BALTIMORE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: NIKOLOVA, EVGENIA NIKOLAEVNA — JOHNS HOPKINS UNIVERSITY
- Study coordinator: NIKOLOVA, EVGENIA NIKOLAEVNA
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Cancers