Understanding how certain proteins interact and function in human health and disease
Low-complexity domain protein molecular structure, conformational dynamics, and inter-protein interactions in human health and disease
This study is looking at how certain proteins help build important structures in our cells, which is key for keeping us healthy, and it aims to understand how changes in these proteins might relate to different health issues.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Connecticut Storrs NIH-funded |
| Lab location | 1 site (Storrs-Mansfield, United States) |
| Project ID | NIH-11065766 on NIH RePORTER |
What this research studies
This research investigates the role of low-complexity domain proteins in the assembly of biomolecules within cells, which is crucial for maintaining biological functions. By using advanced techniques like nuclear magnetic resonance and cryo-electron microscopy, the study aims to characterize the molecular structure and dynamics of these proteins. The research will explore how genetic mutations and protein interactions affect the assembly processes of these proteins, which are important for forming cellular structures like RNA granules and intermediate filaments. This work could provide insights into various health conditions linked to these proteins.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with genetic mutations or conditions associated with low-complexity domain proteins, such as certain neurodegenerative disorders.
Not a fit: Patients with conditions unrelated to protein assembly or those without genetic mutations affecting these proteins may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to a better understanding of diseases related to protein dysfunction, potentially informing new treatment strategies.
How similar studies have performed: Other research has shown promising results in understanding protein interactions and their implications in various diseases, suggesting that this approach could yield valuable insights.
Where this research is happening
Storrs-Mansfield, United States
- University of Connecticut Storrs — Storrs-Mansfield, United States (Active)
Researchers
- Principal investigator: Murray, Dylan Thomas — University of Connecticut Storrs
- Study coordinator: Murray, Dylan Thomas
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.