Understanding how certain proteins interact and function in cells
Emergent cellular functions of GPCRs and myosins
This study is looking at how certain proteins in our cells work together to send signals and move things around, which could help us find new ways to treat diseases related to these processes, benefiting patients in the long run.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Minnesota NIH-funded |
| Lab location | 1 site (Minneapolis, United States) |
| Project ID | NIH-11126893 on NIH RePORTER |
What this research studies
This research investigates the dynamic interactions between proteins involved in cell signaling and membrane traffic, focusing on G protein-coupled receptors (GPCRs) and myosins. By developing innovative protein engineering and biophysical technologies, the project aims to uncover how these proteins communicate and function together in a crowded cellular environment. The research includes creating novel biosensors to measure the effectiveness of GPCR ligands and exploring how these interactions can lead to new therapeutic strategies for diseases. Patients may benefit from advancements in understanding and treating conditions related to cell signaling and function.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research include individuals with conditions related to GPCR signaling or cardiac failure.
Not a fit: Patients with conditions unrelated to GPCR signaling or those not experiencing cellular dysfunction may not receive benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for diseases related to cell signaling dysfunction.
How similar studies have performed: Other research has shown success in understanding protein interactions and their implications for disease, making this approach promising.
Where this research is happening
Minneapolis, United States
- University of Minnesota — Minneapolis, United States (Active)
Researchers
- Principal investigator: Sivaramakrishnan, Sivaraj — University of Minnesota
- Study coordinator: Sivaramakrishnan, Sivaraj
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.