Understanding how certain proteins interact and function in cells
Multiscale Characterization of a Unique Class of Duplex, Multivalent IDP systems
This study is looking at special proteins that don’t have a fixed shape but are really important for how our cells work, and by understanding how they interact with other proteins, we hope to learn more about their role in diseases like cancer and brain disorders, which could help patients in the future.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Oregon Health & Science University NIH-funded |
| Lab location | 1 site (Portland, United States) |
| Project ID | NIH-10886596 on NIH RePORTER |
What this research studies
This research investigates a specific class of proteins known as intrinsically disordered proteins (IDPs) that play crucial roles in cellular functions. By examining how these proteins form complex structures and interact with other proteins, the study aims to uncover the molecular mechanisms behind their functionality. The approach combines advanced computational modeling with experimental techniques like calorimetry and microscopy to provide a detailed understanding of these protein interactions. Patients may benefit from insights gained into how these proteins contribute to various diseases, including cancers and neurodegenerative disorders.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research include individuals with cancers or degenerative neurologic disorders related to protein interactions.
Not a fit: Patients with conditions unrelated to protein dysfunction or those not affected by the diseases being studied may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for treating diseases linked to protein dysfunction.
How similar studies have performed: Other research has shown success in understanding protein interactions and their implications in disease, suggesting that this approach could yield valuable insights.
Where this research is happening
Portland, United States
- Oregon Health & Science University — Portland, United States (Active)
Researchers
- Principal investigator: Zuckerman, Daniel M — Oregon Health & Science University
- Study coordinator: Zuckerman, Daniel M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.