Understanding how certain proteins influence embryonic development and disease
In vivo motif selectivity and functionality of TALE family TFs
This study is looking at how certain proteins, called TALE transcription factors, help with the development of embryos and how cells work, which could give us important insights into birth defects and cancer.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Colorado Denver NIH-funded |
| Lab location | 1 site (Aurora, UNITED STATES) |
| Project ID | NIH-10821388 on NIH RePORTER |
What this research studies
This research investigates the roles of TALE family transcription factors (TFs) in embryogenesis and cellular function. By examining how these proteins interact with DNA and each other in living organisms, the study aims to clarify their specific functions and how they may differ from what is observed in laboratory settings. The research employs advanced techniques to analyze the binding preferences and functional impacts of these TFs in native biological systems, which is crucial for understanding their roles in congenital abnormalities and cancers.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with congenital abnormalities or cancers that may be linked to transcription factor dysfunction.
Not a fit: Patients with conditions unrelated to transcription factor activity or those who do not have congenital abnormalities or cancers may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new insights into the causes of birth defects and cancers, potentially informing future treatments or preventive strategies.
How similar studies have performed: While the specific approach of this research may be novel, similar studies have successfully elucidated the roles of other transcription factors in development and disease.
Where this research is happening
Aurora, UNITED STATES
- University of Colorado Denver — Aurora, United States (Active)
Researchers
- Principal investigator: Sagerstrom, Charles G — University of Colorado Denver
- Study coordinator: Sagerstrom, Charles G
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.