Understanding how certain proteins influence cell development and function.
Mechanisms of p300 Activation During Pluripotency and Differentiation.
['FUNDING_R01'] · UT SOUTHWESTERN MEDICAL CENTER · NIH-11093440
This study is looking at how certain proteins help control cell development, which is important for understanding and potentially preventing birth defects caused by problems in this process, so it could help patients with developmental disorders.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UT SOUTHWESTERN MEDICAL CENTER (nih funded) |
| Locations | 1 site (DALLAS, UNITED STATES) |
| Trial ID | NIH-11093440 on ClinicalTrials.gov |
What this research studies
This research investigates the role of specific proteins, known as enhancers, in the process of pluripotency, which is crucial for determining how cells develop and function. By examining how these enhancers regulate gene expression, the study aims to uncover the molecular mechanisms that could lead to congenital diseases when these processes go awry. The research utilizes advanced techniques to analyze the activity of transcriptional coactivators like p300 and their impact on gene regulation in embryonic stem cells. Patients may benefit from insights gained into developmental disorders linked to enhancer dysregulation.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research include individuals with congenital diseases or developmental disorders.
Not a fit: Patients with conditions unrelated to cellular development or enhancer function may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for understanding and potentially treating congenital diseases linked to cell development.
How similar studies have performed: Other research has shown promising results in understanding enhancer functions and their implications in developmental biology, suggesting that this approach is building on established findings.
Where this research is happening
DALLAS, UNITED STATES
- UT SOUTHWESTERN MEDICAL CENTER — DALLAS, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: BANASZYNSKI, LAURA — UT SOUTHWESTERN MEDICAL CENTER
- Study coordinator: BANASZYNSKI, LAURA
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.