Understanding how certain proteins influence cancer development and progression
Official title: Exploiting oncogenic chromatin regulators in cancer initiation and progression
Funded at University of Colorado Denver · NIH-11198816 · Data updated 2026-11-12
This study is looking at how a protein called KAP1 affects colorectal cancer by helping to activate a process that fuels tumor growth, and it hopes to find new ways to block this process to create better treatment options for patients.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Colorado Denver NIH-funded |
| Lab location | 1 site (Aurora, UNITED STATES) |
| Project start | December 1, 2024 |
| Project end | November 30, 2027 |
| Funding year | 2025 |
| Award (this year) | $97,709 |
| NIH project number | 7K00CA264296-04 |
| Project ID | NIH-11198816 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with colorectal cancer, particularly those with alterations in WNT signaling pathways.
✕Less likely to help
Patients with cancers unrelated to WNT signaling or those without genetic alterations in the pathways being studied may not benefit from this research.
What this research studies
This research investigates the role of specific chromatin regulators in cancer, particularly focusing on the KAP1 protein and its involvement in colorectal cancer. By examining how KAP1 activates WNT signaling, which is crucial for tumor growth, the research aims to uncover new molecular mechanisms that could be targeted for therapy. Patients may benefit from insights gained about how to inhibit WNT signaling, potentially leading to new treatment options for colorectal cancer. The approach includes detailed molecular studies and assays to understand the interactions between KAP1 and other proteins involved in cancer progression.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for colorectal cancer by targeting the mechanisms that drive tumor growth.
How similar studies have gone: Previous research has shown promising results in targeting oncogenic pathways in cancer, suggesting that this approach could yield significant advancements.
Where this research is happening
-
University of Colorado Denver
Aurora, United States Active
Researchers
- Principal investigator: Hyder, Usman — University of Colorado Denver
- Study coordinator: Hyder, Usman
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.