Understanding how certain proteins influence blood cell development
Official title: PROBING CONTROL OF DEVELOPMENTAL EPIGENETIC CHANGE USING RUNX FACTORS
Funded at California Institute of Technology · NIH-11023122 · Data updated 2026-11-12
This study is looking at how certain proteins help T cells, which are important for our immune system, develop and decide what type of cells they will become, and it could help us understand how blood cells are made and controlled.
Quick facts
| Grant type | R37 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | California Institute of Technology NIH-funded |
| Lab location | 1 site (Pasadena, United States) |
| Project start | February 2, 2024 |
| Project end | December 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $769,525 |
| NIH project number | 5R37AI178114-02 |
| Project ID | NIH-11023122 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with conditions related to blood cell formation or immune system dysfunction.
✕Less likely to help
Patients with unrelated health conditions or those not affected by blood cell or immune system issues may not benefit from this research.
What this research studies
This research investigates the role of Runx family transcription factors in the development of T cells, which are crucial for the immune system. By examining how these proteins interact with chromatin states, the study aims to uncover the mechanisms that dictate cell identity and development. The approach involves analyzing changes in transcription factor activity during different stages of T cell development, particularly focusing on lineage commitment. This could provide insights into how blood cells are formed and regulated.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for manipulating blood cell development, which may benefit patients with blood disorders or immune deficiencies.
How similar studies have gone: Previous research has shown promising results in understanding transcription factors and their role in cell development, indicating that this approach has potential for success.
Where this research is happening
-
California Institute of Technology
Pasadena, United States Active
Researchers
- Principal investigator: Rothenberg, Ellen V. — California Institute of Technology
- Study coordinator: Rothenberg, Ellen V.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.