Understanding how certain proteins influence appetite through endocannabinoid signaling
Official title: Molecular Drivers of FABP-mediated Endocannabinoid Signaling for Appetite Regulation
Funded at City College of New York · NIH-11170259 · Data updated 2026-11-12
This study is looking at how certain proteins in our body help control our appetite by working with natural chemicals called cannabinoids, which could help us understand why some people gain weight while others stay lean, and it’s a great opportunity for trainees from different backgrounds to learn together.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | City College of New York NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | August 15, 2022 |
| Project end | July 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $25,374 |
| NIH project number | 3R16GM145403-03S3 |
| Project ID | NIH-11170259 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals struggling with obesity or metabolic disorders related to appetite regulation.
✕Less likely to help
Patients who do not have issues with appetite regulation or obesity may not benefit from this research.
What this research studies
This research investigates the role of fatty acid-binding proteins (FABPs) in regulating appetite through the signaling of endogenous cannabinoids (ECs). By examining how these proteins interact with ECs and their effects on metabolic processes, the study aims to uncover mechanisms that could lead to obesity or lean outcomes. The research will involve laboratory experiments to analyze the binding and transport of ECs at physiological levels, providing insights into how these interactions affect appetite regulation. Trainees from diverse backgrounds will participate in this research, contributing to a collaborative learning environment.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for managing appetite and obesity, potentially improving weight management and metabolic health for patients.
How similar studies have gone: While the specific interactions being studied are novel, previous research has shown that understanding metabolic signaling can lead to significant advancements in obesity treatment.
Where this research is happening
-
City College of New York
New York, United States Active
Researchers
- Principal investigator: Stark, Ruth E. — City College of New York
- Study coordinator: Stark, Ruth E.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.