Understanding how certain proteins in immune cells affect inflammation and tissue repair
Official title: Crosstalk between CES1 and PPAR gamma and LXR alpha in macrophages
Funded at Mississippi State University · NIH-10359914 · Data updated 2026-11-12
This study is looking at how a protein called CES1 affects immune cells, especially in how they handle inflammation, which is important for people dealing with chronic conditions like atherosclerosis, and it hopes to find new ways to help reduce inflammation and improve treatment options.
Quick facts
| Grant type | R15 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Mississippi State University NIH-funded |
| Lab location | 1 site (Mississippi State, United States) |
| Project start | February 15, 2022 |
| Project end | January 31, 2026 |
| Funding year | 2022 |
| Award (this year) | $420,691 |
| NIH project number | 1R15HL157818-01A1 |
| Project ID | NIH-10359914 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals suffering from chronic inflammatory conditions such as atherosclerosis or lung fibrosis.
✕Less likely to help
Patients with acute inflammatory conditions or those not affected by chronic inflammation may not benefit from this research.
What this research studies
This research investigates the interactions between specific proteins and lipids in immune cells, particularly macrophages, which play a crucial role in inflammation and tissue repair. The study focuses on how a protein called CES1 influences the activity of receptors that can either promote or resolve inflammation when exposed to harmful substances. By exploring these mechanisms, the research aims to uncover how chronic inflammatory conditions, like atherosclerosis, develop and how they might be treated. Patients may benefit from insights that could lead to new anti-inflammatory therapies.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for chronic inflammatory diseases, improving patient outcomes.
How similar studies have gone: Other research has shown promising results in understanding the role of lipid interactions in inflammation, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Mississippi State University
Mississippi State, United States Active
Researchers
- Principal investigator: Ross, Matthew K — Mississippi State University
- Study coordinator: Ross, Matthew K
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.