Understanding how certain proteins help transport drugs in the body
Official title: Molecular Basis of Substrate Translocation in the Drug/H+ Antiporter 1 Family
Funded at Rosalind Franklin Univ of Medicine & Sci · NIH-11073017 · Data updated 2026-11-12
This study is looking at how certain proteins help move medications in and out of cells, which could explain why some infections and diseases become resistant to treatment, and the results might help improve therapies for conditions like alcoholism and autism.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Rosalind Franklin Univ of Medicine & Sci NIH-funded |
| Lab location | 1 site (North Chicago, United States) |
| Project start | June 15, 2022 |
| Project end | April 30, 2026 |
| Funding year | 2025 |
| Award (this year) | $327,600 |
| NIH project number | 5R01GM145642-04 |
| Project ID | NIH-11073017 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals struggling with alcoholism, autism spectrum disorders, or related neurological conditions.
✕Less likely to help
Patients with conditions unrelated to drug transport mechanisms or those not affected by alcoholism or autism may not benefit from this research.
What this research studies
This research investigates the molecular mechanisms of drug transport proteins that play a crucial role in how medications are moved across cell membranes. By studying a specific protein from E. coli, the researchers aim to uncover how these proteins can contribute to drug resistance in infections and other diseases. The findings could lead to new strategies for overcoming resistance and improving treatment options for conditions like alcoholism and autism spectrum disorders. Patients may benefit from insights that could enhance the effectiveness of existing therapies.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for conditions like alcoholism and autism by targeting drug transport mechanisms.
How similar studies have gone: Previous research has shown promise in targeting drug transport mechanisms to combat antimicrobial resistance and improve treatment outcomes, indicating that this approach has potential for success.
Where this research is happening
-
Rosalind Franklin Univ of Medicine & Sci
North Chicago, United States Active
Researchers
- Principal investigator: Lu, Min — Rosalind Franklin Univ of Medicine & Sci
- Study coordinator: Lu, Min
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.