Understanding how certain proteins help repair DNA damage
Mechanisms and Functions of Iron-Sulfur Helicases in DNA repair
This study is looking at how certain proteins help fix DNA damage that can cause diseases like cancer, and it's for anyone interested in understanding how our cells protect themselves from problems during DNA copying.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Florida NIH-funded |
| Lab location | 1 site (Gainesville, United States) |
| Project ID | NIH-10910047 on NIH RePORTER |
What this research studies
This research investigates the role of iron-sulfur helicases, a type of protein, in repairing DNA damage that can lead to diseases like cancer. By studying these proteins, the research aims to uncover how they help cells bypass or fix DNA damage during replication. The approach involves biochemical and molecular techniques to analyze the mechanisms of these helicases, particularly focusing on a newly identified member of this family in bacteria. The findings could provide insights into the importance of these proteins in maintaining genomic stability and preventing diseases associated with DNA damage.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with genetic disorders or cancers associated with DNA repair mechanisms.
Not a fit: Patients with conditions unrelated to DNA damage or repair mechanisms may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and potential treatments for genetic disorders and cancers linked to DNA repair deficiencies.
How similar studies have performed: Previous research has shown success in understanding DNA repair mechanisms, indicating that this approach has the potential for meaningful advancements.
Where this research is happening
Gainesville, United States
- University of Florida — Gainesville, United States (Active)
Researchers
- Principal investigator: Bloom, Linda B — University of Florida
- Study coordinator: Bloom, Linda B
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.