Understanding how certain proteins help repair DNA and prevent cancer
Structure and function of RAD51 paralog tumor suppressor complexes in genome maintenance
This study is looking at how certain proteins help fix DNA damage, which is important for keeping our genes healthy and preventing cancers like breast and ovarian cancer, so that we can better understand how changes in these proteins might lead to cancer and find new ways to treat it.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Texas Hlth Science Center NIH-funded |
| Lab location | 1 site (San Antonio, United States) |
| Project ID | NIH-11088269 on NIH RePORTER |
What this research studies
This research investigates the role of RAD51 paralogs in the repair of DNA damage, which is crucial for maintaining genome integrity and preventing cancer. The study focuses on how these proteins interact during the process of homologous recombination, a key mechanism for repairing double-strand breaks in DNA. By examining the structural and molecular functions of specific protein complexes, the research aims to uncover how mutations in these proteins can lead to cancer, particularly breast and ovarian cancers. Patients may benefit from insights gained into the mechanisms of cancer susceptibility and potential therapeutic targets.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with a family history of breast or ovarian cancer or those diagnosed with related cancers due to genetic mutations.
Not a fit: Patients without a genetic predisposition to breast or ovarian cancer or those not affected by DNA repair deficiencies may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding of cancer mechanisms and new strategies for prevention or treatment.
How similar studies have performed: Previous research has shown that understanding DNA repair mechanisms can lead to significant advancements in cancer treatment, indicating a promising avenue for this study.
Where this research is happening
San Antonio, United States
- University of Texas Hlth Science Center — San Antonio, United States (Active)
Researchers
- Principal investigator: Olsen, Shaun — University of Texas Hlth Science Center
- Study coordinator: Olsen, Shaun
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.