Understanding how certain proteins help repair DNA and prevent cancer
Mechanisms of DNA Homology-directed Genome Repair and Tumor Suppression
This study is looking at how certain proteins help fix DNA damage, which is important for keeping our genes healthy, especially in people with breast and ovarian cancers, and aims to find new ways to treat these conditions by understanding how these proteins work.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Texas Hlth Science Center NIH-funded |
| Lab location | 1 site (San Antonio, United States) |
| Project ID | NIH-10898782 on NIH RePORTER |
What this research studies
This research investigates the mechanisms of homology-directed DNA repair (HDR), which is crucial for fixing DNA damage and maintaining genomic stability. It focuses on the roles of tumor suppressor proteins such as BRCA1, BARD1, and BRCA2, which are linked to breast and ovarian cancers when mutated. The research team aims to purify these proteins for detailed studies and will collaborate with experts in structural biology to explore how these proteins function in HDR. Additionally, they will conduct chemical screenings to develop potential inhibitors that could be used in future treatments.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with a family history of breast or ovarian cancer, particularly those with known mutations in BRCA1 or BRCA2 genes.
Not a fit: Patients without a genetic predisposition to breast or ovarian cancer or those not carrying mutations in the BRCA genes may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for patients with breast and ovarian cancers linked to BRCA mutations.
How similar studies have performed: Previous research has shown promising results in understanding DNA repair mechanisms and their implications for cancer treatment, indicating that this approach has potential for success.
Where this research is happening
San Antonio, United States
- University of Texas Hlth Science Center — San Antonio, United States (Active)
Researchers
- Principal investigator: Sung, Patrick — University of Texas Hlth Science Center
- Study coordinator: Sung, Patrick
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.